Disease information

South Africa has played a leading role in the control of malaria for almost a century and has dramatically reduced its burden of malaria since 2000. This has paved the way for our commitment to eliminate malaria.

However, this success brings its own challenges, including the fact that the majority of malaria cases in South Africa are now imported (i.e. not locally transmitted), and often present late and to health facilities in malaria-free areas. Thus, health professionals throughout South Africa, in both the malaria-endemic and malaria-free areas, all need to develop and maintain their knowledge and skills in malaria diagnosis and treatment.

These guidelines are based on the 2015 World Health Organization’s Guidelines for the treatment of malaria. Additional literature surveys have been undertaken. Factors that were considered in the choice of therapeutic options included effectiveness, safety, and impact on malaria transmission and on the emergence and spread of antimalarial drug resistance. On-going surveillance is critical given the spread of artemisinin resistance in Southeast Asia, although not yet confirmed anywhere in Africa.

The guidelines on the treatment of malaria in South Africa that aim to facilitate effective, appropriate and timeous treatment of malaria, thereby reducing the burden of this disease in our communities. This is essential to further bring down the malaria case fatality rates currently recorded in South Africa, to decrease malaria transmission and to limit resistance to antimalarial drugs.

The malaria risk map as released by the Department of Health. Map produced by the Health GIS Centre, Malaria Research Unit and South African Medical Research Council. To significantly reduce your risk, take precautionary measures against mosquito bites throughout the year in ALL RISK areas. Where malaria chemoprophylaxis is indicated, mefloquine or doxycycline or atovaquone proguanil should be used.

The information provided for each country includes the country's stated requirements for yellow fever vaccination, WHO recommendation for travellers regarding yellow fever vaccinations, and details concerning the malaria situation and recommended prevention of the disease

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Important Notice

You are advised to visit your general practice surgery or a travel medicine clinic at least 6 weeks before you travel. However, it is never too late to seek advice.

If you have a medical condition, you are advised to discuss the suitability of the trip before you book.


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